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Publication mSystems, MOSAR
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Publication mSystems, MOSAR

A dynamic genomic model of a key rumen ecosystem bacterium

The rumen microbiota plays an essential role in ruminant nutrition, degrading plant feed and transforming it into a source of energy and protein for the animal. In a collaborative review published in mSystems and coordinated by Rafael Muñoz-Tamayo of the UMR Modélisation Systémique Appliquée aux Ruminants - MoSAR (INRAE/AgroParisTech/UPSaclay, Palaiseau), the authors focused on the key rumen bacterium Fibrobacter succinogenes S85, which degrades cellulose and produces succinate.

The metabolic functions of F. succinogenes are central to the rumen ecosystem and are of particular interest for several industrial applications. The authors of the study followed an interdisciplinary approach that combines microbiology, computational biology and mathematical modeling to investigate how information from the F. succinogenes genome can be translated to develop predictive dynamic models of rumen fermentation processes.

This type of approach can be applied to other rumen microbes to produce a rumen microbiome model that can be used to investigate microbial manipulation strategies to improve feed utilization and mitigate enteric emissions by ruminants. This work follows open science principles: open access, open data, open code, open peer-review.

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Ibrahim Fakih, Jeanne Got, Carlos Eduardo Robles-Rodriguez, Anne Siegel, Evelyne Forano, Rafael Muñoz-Tamayo. Dynamic genome-based metabolic modeling of the predominant cellulolytic rumen bacterium Fibrobacter succinogenes S85. mSystems, Volume 8, issue 3 e01027-22
https://doi.org/10.1128/msystems.01027-22

Modification date: 02 November 2023 | Publication date: 29 June 2023 | By: Edition P. Huan