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MiTick team (UMR-BIPAR) obtained prestigious awards during TTP11 conference in Havana/Varadero Cuba 1st – 6th September 2024. From left: Ladislav Simo (Head of MiTick), PhD candidate Lianet Abuin-Denis (1st place for the best student poster of the conference), PhD candidate Stefania Porcelli (2nd place for the best student oral presentation of the conference), Sara Moutailler (Head of UMR-BIPAR).
article

10 October 2024

By: UMR BIPAR

11th Tick and Tick-Borne Pathogen Conference (TTP11) in Havana/Varadero, Cuba, 1st-6th September 2024

During 1st – 6th September multiple members of UMR-BIPAR MiTick team, Maisons-Alfort France (groups: VAMP, Ticks&Co, microBioTick and NeuroTick) contributed to the 11th Tick and Tick-Borne Pathogen Conference (TTP11) in Havana/Varadero in Cuba.
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article

03 October 2024

By: ANAXEM

MICALIS Institute's ANAXEM platform joins SAPS!

The Anaxem experimental unit is an animal facility for rodents and birds, either germ-free or with controlled microbiota, kept in sterile isolators. It provides research teams from Institut Micalis, INRAE and other organizations (academic and private) with animals, infrastructure and technical assistance to carry out protocols on the dialogue between the commensal microbiota and its host.
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article

01 October 2024

By: SAPS VIM IERP

In vivo exploration of the infectious processes of spring viraemia virus of carp (SVCV): an integrated approach from model organism to target species.

Aquaculture is the fastest-growing food production sector, albeit hampered by environmental and ecological crises and epidemics. Carp spring viraemia virus (CSVV) is a notifiable pathogen of major interest, for which there is no vaccine, and whose disease can be modeled in zebrafish (ZF).
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article

01 October 2024

By: UMR GABI

A major article on the origin and precise dating of the domestication of Equus caballus 4200 years ago in the Don Valley.

Tous les chevaux domestiques vivant sur terre, qu'ils soient champions de courses ou compagnons de club équestre, trouvent leurs origines dans la vallée du Don au sud-ouest de la Russie, mais la chronologie exacte de leur intégration généralisée dans les sociétés humaines divise encore la communauté scientifique. Une étude publiée le 6 juin dans la revue Nature démontre que l’essor des chevaux domestiques n’a commencé qu’il y a 4 200 ans environ. Cette date marque une nouvelle ère dans l'histoire humaine où les chevaux ont révolutionné la vitesse des déplacements et des échanges entre les peuples. Ces recherches ont été coordonnées par une équipe du CNRS et de l’université Toulouse III – Paul Sabatier dirigée par Ludovic Orlando au sein du Centre d’anthropobiologie et de génomique de Toulouse1 et impliquent 133 scientifiques, issus de 113 institutions à travers le monde.
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article

06 June 2024

By: GABI

14th International Havemeyer Foundation Horse Genome Workshop a great success

The 14th Havemeyer Horse Genome Workshop was held from May 12 to 15, 2024 at the University of Caen, bringing together an international community of 110 people to share scientific results on the horse genome. A resounding success that will undoubtedly raise the international profile of INRAE, the GABI unit, LABÉO, the city of Caen and the Normandy region.
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INRAE Photothèque
article

18 April 2024

By: GABI

SOCS2 mutation induces structural and functional changes in mammary gland development.

Lactation is an essential process for mammals. In sheep, the R96C mutation in the SOCS2 (Suppressor Of Cytokine Signaling 2) protein is associated with higher milk production and increased susceptibility to mastitis. To understand the involvement of the R96C mutation in mammary gland development and lactation, we developed a mouse model carrying this mutation (SOCS2KI/KI).
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INRAE Phototheque 9031-095
article

18 April 2024

By: GABI

Effects of genetic variants on gene regulation in pigs

Understanding the molecular bases controlling complex traits in livestock is essential for optimizing genetic selection methods and thus improving breeding.
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INRAE Photothèque
article

16 April 2024

By: GABI

SOCS2 mutation induces structural and functional changes in mammary gland development.

Lactation is an essential process for mammals. In sheep, the R96C mutation in the SOCS2 (Suppressor Of Cytokine Signaling 2) protein is associated with higher milk production and increased susceptibility to mastitis. To understand the involvement of the R96C mutation in mammary gland development and lactation, we developed a mouse model carrying this mutation (SOCS2KI/KI).
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@INRAE M. Dupont-Nivet
article

22 March 2024

By: GABI

Sélection et dynamique de la diversité génétique chez la truite arc-en-ciel

Any animal or plant population, wild or domesticated, evolves through continuous and cumulative changes over time, based on various evolutionary forces, namely selection, genetic drift, mutation and migration, with relative effects that depend on population history and structure. The footprints left along the genome by these evolutionary processes may correspond to positive selection of favorable alleles, resulting in highly homozygous regions with low genetic diversity, or, on the contrary, to balancing selection phenomena enabling regions to be maintained in a heterozygous state and thus with high genetic diversity.
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@INRAE Bertrand Nicolas
article

22 March 2024

By: INRAE

Select trout that are more resistant to heat waves

Climate change is already causing, and will continue to cause, more and more heat waves. These heat waves have a negative effect on water quality in aquaculture farms: higher temperatures and lower levels of available oxygen in the water. Technical solutions are available to limit these sometimes rapid and severe variations in temperature and oxygenation in trout farms, but they are often costly. Selecting animals that can withstand these heat waves is therefore a promising way of coping with the impact of climate change. Scientists at INRAE, in collaboration with SYSAAF (the French poultry and aquaculture breeders' association) and two French trout breeding companies, have studied the feasibility of breeding for resistance to hyperthermia (exposure to high temperatures) and/or hypoxia (exposure to reduced oxygen levels).
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article

20 February 2024

By: INRAE

Prestigious AAAS award for the study of ancient DNA in Native American horses

The prestigious Newcomb Cleveland 2024 prize awarded for a publication on the ancient DNA of horses bred and used by indigenous peoples of the North American plains, published in the journal Science in 2023. An interdisciplinary team of American Indian and Western scientists, coordinated by Ludovic Orlando (CNRS Toulouse) and William Timothy Treal Taylor (University of Colorado), has been selected to receive the Newcomb Cleveland 2024 Award (AAAS) for their work on the genetic origins of the first horses bred and used by the indigenous peoples of the North American plains.
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article

08 February 2024

By: INRAE

INRAE researchers competition

Find out about open positions to join SAPS member units! Application deadline: March 5, 2024
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article

29 January 2024

By: SAPS

A high-fat maternal diet alters the composition of the embryonic microenvironment and induces an embryonic sex-specific gene response as early as the pre-implantation stage.

Over the last few decades, eating habits have changed and fat consumption has increased. Combined with low energy expenditure, excessive fat intake contributes to an increase in metabolic diseases that now affect young populations of childbearing age. This study explored the impact of a high-fat maternal diet on the embryo prior to implantation in the uterus, using the rabbit as a model animal. This work is published in Journal of Developmental Origins of Health and Disease.
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article

29 January 2024

By: PH

Understanding pig embryo development: an asset for breeding tomorrow's animals

In a study published in Genomics, scientists from the UMR Génétique Animale et Biologie Intégrative - GABI (INRAE/AgroParisTech/UPSaclay, Jouy-en-Josas) have characterized the transcriptome of 35,000 embryonic cells derived from pig embryos between 5 and 11 days after fertilization. They were able to identify new sub-populations of embryonic cells, both for the secretion of molecules required for implantation, such as those expressing interleukin 1 beta (IL1B), and a population of stem cells expressing LRP2, which will subsequently contribute to the development of the embryonic placenta.
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@INRAE Emilie Derisoud
article

27 November 2023

By: PH

Une nouvelle méthode pour détecter et quantifier la transmission transgénérationnelle des effets environnementaux afin de faciliter l’adaptation des animaux aux conditions d’élevage de demain

In a study published in Genetic Selection Evolution, researchers from the BIGE team (Génétique Animale et Biologie Intégrative - GABI, INRAE/AgroParisTech/UPSaclay, Jouy-en-Josas) have proposed a new model identifying the transmission of environmental effects based on the analysis of phenotypes and pedigrees.
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article

27 November 2023

By: PH

DMRT1, a key player in male sex determination and female fertility in rabbits

In an article published in eLife, researchers from the Laboratory of Reproductive Biology, Environment, Epigenetics and Development - BREED (UMR 1198 INRAE/UPSaclay, Jouy-en-Josas) demonstrate, for the first time in a mammal, the involvement of the transcription factor DMRT1 in sex determination and gonad differentiation.
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GIE LCH (Contrôle anti-dopage équin de macromolécules biothérapeutiques)
article

02 November 2023

By: GIE LCH - Edition P. Huan - Translation W Brand-Williams

A new method for high-throughput screening for the analysis of therapeutic monoclonal antibodies and fusion proteins for the control of equine anti-doping

This development allows extending the analytical capacities of equine anti-doping control laboratories to biotherapeutic macromolecules made up of immunoglobulins such as monoclonal antibodies and fusion proteins, using a sensitive, specific and robust high-throughput method.
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@Pixabay
article

02 November 2023

By: INRAE - Edition P. Huan - Translation W. Brand-Williams

Equine research: INRAE and LABÉO reinforce their partnership

On July 13th in Caen, the Franck Duncombe LABEO laboratory and INRAE signed a framework partnership agreement for research in genetics and health in the horse, and more generally in animal health and the environment. The Intergrative Biology and Equine Genetics team of UMR GABI (INRAE Jouy) will develop its research projects as part of this framework, notably on equine influenza, genomic selection and myopathy in the race horse. This partnership will be visible internationally from May 12 to 15, 2024, since the two laboratories will organize together the 14th International Havemeyer Horse Genome Workshop where approximately one-hundred scientists will gather at the castle in Caen.
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article

02 November 2023

By: INRAE - Edition P. Huan

X chromosome genes influence dairy cow performance

In cattle, as in other mammals, the genome is made up of several pairs of homologous chromosomes or autosomes (present in 29 pairs in cows) and a pair of sex chromosomes, X and Y. Females have two copies of the X chromosome, while males have one copy of each of the X and Y chromosomes. Females have 2 copies of the X chromosome, while males have one copy of each X and Y chromosome. Although it contains a large number of genes, the X chromosome is often overlooked in genomic studies, as it is present in only one copy in males. A team of INRAE and Eliance researchers from the Animal Genetics and Integrative Biology unit (GABI) has assessed the role of the X chromosome and the genes it harbors on key traits for the sustainability of cattle breeding. Their work, published in the journal BMC Genomics, reveals the importance of the X chromosome in the genetic determination of traits, and identifies the genes probably responsible for its effects.
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INRAE - Luc Delaby
article

02 November 2023

By: INRAE - Edition P. Huan

When cattle chromosomes get tangled: detecting genetic defects to better prevent them

In cattle, like in all animals, genetic material is contained in pairs of chromosomes, each set of which is randomly distributed when gametes (spermatoza or ovocytes) are formed. During that process, genetic material from one chromosome sometimes gets shifted to another chromosome that is not part of the same pair, and this is known as interchromosomal rearrangement. Fertilisation with a gamete containing a one or more rearranged chromosomes will cause the embryo to have fewer or more genes than normal, which is, in most cases, fatal. For the first time, INRAE geneticists, in collaboration with colleagues from ELIANCE (French national livestock breeders federation), have conducted a population study (on 5571 insemination bulls) to quantify the frequency of such defects, their origins and the consequences they have on livestock. Their results, published in Genome Research, reveal that 1 bull in 450 may be a carrier of an interchromosomal rearrangement, whose consequences on the affected animals' health and fertility may cost the sector more than one million euros for each insemination sire that is a carrier. This study is based on the millions of genotyping data routinely generated for genomic evaluation of insemination bulls and their progeny (offspring). The approach used is the first step towards widespread screening for such chromosomal anomalies.
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INRAE M. Dupont-Nivet
article

02 November 2023

By: Edition P. Huan

Genetic selection could help reduce trout farm mortality during heat waves

In a study published in Genetics Selection Evolution, scientists from the UMR de Génétique Animale et Biologie Intégrative - GABI (INRAE/AgroParisTech/UPSaclay, Jouy-en-Josas) have described the genetic architecture of resistance to acute hyperthermia, i.e. the ability of fish to survive high temperatures. They have shown that 29% of performance variation in this trait is genetic in origin in a French commercial population, attesting to significant potential for genetic improvement. Genetic correlations of this trait with the main production traits - growth, % intramuscular fat and carcass yield - are close to zero. Selection for resistance to acute hyperthermia should therefore have no impact on these traits, and vice versa.
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